Dr. Banerjee is an Assistant Professor of Chemistry and a member of the Molecular Biosciences Ph.D. program at the Middle Tennessee State University. Prior to joining MTSU in August 2022, he served as an Assistant Professor of Chemistry in the Department of Physical Sciences at the University of Arkansas Fort Smith. He received his Ph.D. in Organic Chemistry from the University of Southern Mississippi in 2013. His graduate work was focused on enzyme catalysis driven asymmetric synthesis of unnatural constrained amino acids and peptidomimetics. Before enrolling in the graduate program at USM, he worked as a scientist for Syngene International Ltd., a Biocon Biopharmaceutical Company, on various R&D library synthesis projects for Merck. Dr. Banerjee received postdoctoral training at the University of Tennessee Health Science Center in the laboratories of Professor Duane D. Miller. His postdoctoral research was aimed at design and synthesis of small molecule autotaxin and tubulin polymerization inhibitors for the treatment of resistant cancers. His current research is primarily centered around X-ray crystallography/ molecular modeling guided design and synthesis of small molecules and peptides with anticancer properties.

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1. Alicja Urbaniak, Chandramohan Bathula, Jyoti Chauhan, Prateek Rai, Joshua Thammathong, Cristopher Clark, Billie Heflin, Annick De Loose, Nathan Avaritt, Analiz Rodriguez, Alan J. Tackett, Subhabrata Sen, Souvik Banerjee. Synthesis and Anti-Melanoma Activity of Acryloyl Pyridinone Analogues. Chemistry and Diversity 2023, 20 (12), 1284-1294, e202301550

2. Joshua Thammathong, Kaylee B. Chisam, Garrett E. Tessmer, Carl B. Womack, Mario M. Sidrack, April M. Weissmiller, Souvik Banerjee. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibits Neuroblastoma Cell Function. ACS Medicinal Chemistry Letters 2023, 14 (9), 1284-1294

3. Shanshan Deng, Souvik Banerjee, Hao Chen, Satyanarayana Pochampally, Yuxi Wang, Mi-Kyung Yun, Stephen W. White, Keyur Parmar, Bernd Meibohm, Kelli L. Hartman, Zhongzhi Wu, Duane D. Miller, Wei Li. SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis. Cancer Letters 2023, 555, 216046 

4. Souvik Banerjee, Suechin Lee, Derek D. Norman, Gabor J. Tigyi. Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis. Molecules 2022, 27(17), 5487 

5. Jia Zeng, Jifa Zhang, Ying Sun, Jiaxing Wang, Changyu Ren, Souvik Banerjee, Liang Ouyang, Yuxi Wang. Targeting EZH2 for cancer therapy: From current progress to novel strategies. European Journal of Medicinal Chemistry 2022, 238, 114419

6.  Souvik Banerjee, Salini Yadav, Sourav Banerjee, Sayo O. Fakayode, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Foyez Mahmud, Ryan Whatcott, Joshua Thammathong, Bernd Meibhom, Duane D. Miller, Kshatresh Dutta Dubey. Drug Repurposing to Identify Nilotinib as Potential SARS-CoV-2 Main Protease Inhibitor: An Insight from Computational and In Vitro Study. The Journal of Chemical Information and Modeling 2021, 61, 5469-5483

7. Panchanan Maiti, Jayeeta Manna, Joshua Thammathong, Bobbi Evans, Kshatresh Dutta Dubey, Souvik Banerjee, Gary L. Dunbar. Tetrahydrocurcumin Showed Similar Anti-Amyloid Properties with Curcumin: In Vitro Comparative Structure-Activity Studies. Antioxidants 2021, 10(10), 1592  

8. Souvik Banerjee, Foyez Mahmud, Shanshan Deng, Lingling Ma, Mi-Kyung Yun, Sayo O. Fakayode, Kinsie E. Arnst, Lei Yang, Hao Chen, Zhongzhi Wu, Pradeep B. Lukha, Keyur Parmer, Brend Meibohm, Stephen W. White, Yuxi Wang, Wei Li, Duane Miller. X-Ray Crystallography Guided Design, Antitumor Efficacy and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors. The Journal of Medicinal Chemistry 2021, 64, 13072-13095

9. Souvik Banerjee, Norman, D. Derek, Shanshan Deng, Sayo O. Fakayode, Sue-Chin Lee, Abby L. Parrill, Wei Li, Duane D. Miller, Gabor J. Tigyi. Molecular Modeling Guided Design Synthesis and QSAR Analysis of New Small Molecule Non-Lipid Autotaxin Inhibitors. Bioorganic Chemistry 2020, 103, 104188 

10. Kinsie E. Arnst, Souvik Banerjee, Yuxi Wang, Hao Chen, Young Li, Lei Yang, Weimin Li, Wei Li and Duane D. Miller. X-Ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Highly Potent Tubulin Polumerization Inhibitors. ACS Chemical Biology 2019, 14, 2810-2821 

11. Kinsie E. Arnst ⊥, Souvik Banerjee ⊥, Hao Chen, Shanshan Deng, Dong-Jin Hwang, Wei Li and Duane D. Miller. Current Advances of Tubulin Inhibitors as Dual Acting Small Molecules Targeted Cancer Treatment. Medicinal Research Reviews 2019, 39(4), 1398-1426. (⊥ indicates the co-first authorship) 

12. Souvik Banerjee, Kinsie E. Arnst, Yuxi Wang, Gyanendra Kumar, Shanshan Deng, Lei Yang, Guo-Bo Li, Jinliang Yang, Stephen W. White, Wei Li, and Duane D. Miller. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Anti-Tumor Efficacy. Journal of Medicinal Chemistry 2018, 61(4), 1704-1718 

13. Souvik Banerjee, Derek D. Norman, Sue Chin Lee, Abby L. Parrill, Truc Chi T. Pham, Daniel L. Baker, Gabor G. Tigyi, Duane D. Miller. Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells. Journal of Medicinal Chemistry 2017, 60, 1309-1324 

14. Souvik Banerjee, Dong-Jin Hwang, Wei Li, Duane D. Miller. Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis. Molecules 2016, 21, 1468 

15. Suriyan Ponnusamy, Quynh T. Tran, Innocence Harvey, Heather S. Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel L. Johnson, James T. Dalton, Ryan D. Sullivan, Duane D. Miller, Dave Bridges, Ramesh Narayanan. Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue. FASEB Journal 2016, 31(1), 266-281 

16. Souvik Banerjee, Emily R Vogel, Daniel Hinton, Michael Sterling, Douglas S Masterson. An enantiodivergent synthesis of C α-methyl nipecotic acid analogues from δ-lactam derivatives obtained through a highly stereoselective cyclization strategy. Tetrahedron: Asymmetry 2015, 26(21), 1292-1299 

17. Souvik Banerjee, Jin Wang, Susan Pfeffer, Dejian Ma, Lawrence M Pfeffer, Shivaputra A Patil, Wei Li, Duane D Miller. Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents. Molecules 2015, 20(9), 17152-17165 

18. Andrea Balogh, Yoshibumi Shimizu, Sue Chin Lee, Derek D Norman, Ruchika Gangwar, Mitul Bavaria, ChangSuk Moon, Pradeep Shukla, Radakrishna Rao, Ramesh Ray, Anjaparavanda P Naren, Souvik Banerjee, Duane D Miller, Louisa Balazs, Louis Pelus, Gabor Tigyi. The autotaxin–LPA 2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair. Cell Signal 2015, 27(9), 1751-1762  

19. Sue-Chin Lee, Yuko Fujiwara, Jianxiong Liu, Junming Yue, Yoshibumi Shimizu, Derek D. Norman, Yaohong Wang, Ryoko Tsukahara, Erzsebet Szabo, Renukadevi Patil, Souvik Banerjee, Duane D. Miller, Louisa Balazs, Manik C. Ghosh, Christopher M. Waters, Tamas Oravecz and Gabor J. Tigyi.* Autotaxin, Lysophosphatidic Acid Receptors 1 and 5 Exert Different Functions in Tumor Cells Versus the Host tissue Microenvironment in Melanoma Invasion and Metastasis. Molecular Cancer Research 2015, 13(1), 174-185  

20. Sara L. Morales-Lázaro, Barbara Serrano-Flores, Itzel Llorente, Enrique Hernández-García, Ricardo González-Ramírez, Souvik Bannerjee, Duane Miller, Veeresh Gududuru, James Fells, Derek Norman, Gábor Tigyi, Diana Escalante-Alcalde, and Tamara Rosenbaum. * Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs. The Journal of Biological Chemistry 2014, 289(35), 24079-24090  

21. Souvik Banerjee, Walker J. Wiggins, Catherine T. Anthony, Eugene A. Wolterin, Douglas S. Masterson. * Novel Synthesis of Diverse Orthogonally Protected Cα-Methyl Lysine Analogues and Biological Evaluation of a Vapreotide Analogue Containing (S)-α-Methyllysine. Organic & Biomolecular Chemistry 2013, 11, 6307-6319

22. Souvik Banerjee, Justin Smith, Jillian Smith, Caleb Faulkner, and Douglas S. Masterson. * A Stereoselective Cyclization Strategy for the Preparation of γ-Lactams and Their Use in the Synthesis of α-Methyl-β-Proline. The Journal of Organic Chemistry 2012, 77 (23), 10925-10930

23. Maureen E. Smith, Souvik Banerjee, Yongliang Shi, Marlen Schmidt, Uwe Bornscheuer, and DouglasS. Masterson. * Investigation of the Cosolvent Effect on the Six Isoenzymes of PLE in the Enantioselective Hydrolysis of Select α, α- Disubstituted Malonate Esters.  ChemCatChem 2012, 4(4), 472-475  

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