Ashley Lira-Rivera

• SOAR Position: Member; Alumni
• Major: Biology- Genetics and Biotechnology
• Faculty Mentor(s): Dr. April Weissmiller

Current Focus: Investigating the effect of SNF5 on cell lines derived from small cell carcinoma of the ovary, hypercalcemic type cancers

Additional Interests: I love dancing ballet folklorico because it connects me to my Mexican heritage and culture! Alongside my major, I have minors in Arabic, Psychology, and Chemistry!

Project Description

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive ovarian cancer that is rare and lethal, affecting young women worldwide. The median age at diagnosis is 24 years with the prognosis being poor (~30% survival) even if diagnosed at an early stage. Treatment often includes chemotherapy and surgery to remove at least one ovary but often the cancer returns. The purpose of this project is to validate the newly engineered COV-434 cell lines generated in Dr. Weissmiller's lab. My goal is to optimize the induction parameters and conditions that allow SNF5 expression in the cell to be expressed. SNF5 is a well-studied SWI/SNF subunit that is heavily implicated in cancer and being able to control the absence or presence of SNF5 in SCCOHT cells will allow us to probe the impact of SNF5 and residual SWI/SNF on SCCOHT processes.

Why does this topic interest you?

Genetics is what initially drew me to biology and sparked my passion for understanding the science behind human health. Cancer is a disease that transcends race, gender, and socioeconomic status, affecting everyone in one shape or form, making it both fascinating and terrifying. Exploring how genetic changes drive cancer development not only deepens my understanding of disease mechanisms but also aligns perfectly with my long-standing interest in the intersection of genetics and medicine, making this research incredibly fascinating to me!

What are your professional aspirations?

I hope to attend medical school to become a doctor, with the goal of not only providing patient care but also contributing to research that advances our understanding of diseases and improves treatments.

Do you have any advice for future researchers?

Mistakes are a natural part of the research process—don't be afraid of them! Each misstep presents an opportunity to learn and grow, ultimately making you a more confident and independent researcher. When challenges arise, don’t hesitate to seek guidance; remember that your mentor has been in your shoes and will appreciate your willingness to ask for help. Choosing a mentor you feel comfortable with is crucial, as they can offer valuable support and encouragement throughout your journey. Most importantly, have fun with your research! Not everyone has the opportunity to be involved in this field, so embrace the experience and make the most of it!

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