Research Publications

Almosnid, N.M., Zhou, X., Jiang, L., Ridings, A., Knott, D., Wang, S., Wei, F., Yuan, J., Altman, E., Gao, Y., Miao, J. (2018) Evaluation of extracts prepared from 16 plants used in Yao ethnomedicine as potential anticancer agents. Journal of Ethnopharmacology. 211: 224-234.

Chen, C., Chen, W., Li, Y., Dong, Y., Teng, X., Nong, Z., Pan, X., Gao, Y., Wu, G. (2017) Hyperbaric oxygen protects against myocardial reperfusion injury via the inhibition of inflammation and the modulation of autophagy. Oncotarget. 8: 111522-111534.

Chen, L., Wei, Y., Zhao, S., Zhang, M., Yan, X., Gao, X., Li, J., Gao, Y., Zhang, Z., Gao, Y. (2018) Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H22 liver tumor-bearing mice. Scientific Reports. 8: 10523.

Alsaif, G., Almosnid, N.M., Hawkins, I., Taylor, Z., Knott, D.L.T., Handy, S., Altman, E., Gao, Y. (2017) Evaluation of fourteen aurone derivatives as potential anti-cancer agents. Current Pharmaceutical Biotechnology. 18: 384-390.

Chen, C., Nong, Z., Xie, Q., He, J., Cai, W., Tang, X., Chen, X., Huang, R., Gao, Y. (2017) 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione inhibits the growth and metastasis of breast carcinoma in mice. Scientific Reports. 7: 6704.

Jiang, L., Wu, L., Yang, F., Almosnid, N., Liu, X., Jiang, J., Altman, E., Wang, L., Gao, Y. (2017) Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents. Oncology Letters. 14: 3057-3064.

Park, H.S., Nelson, D.E., Taylor, Z.E., Hayes, J.B., Cunningham, K.D., Arivett, B.A., Ghosh, R., Wolf, L.C., Taylor, KM, Farone, M.B., Handy, S.T., Farone, A.L. (2017) Suppression of LPS-induced NF-κB activity in macrophages by the synthetic aurone, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one. International Immunopharmacology. 43: 116-128. 

Smith, S., DuBois, J., Phillips, N., Clardy, A. (2017) Wild Simulant Production Methods for American Ginseng Farms in Tennessee. Tennessee Agricultural Extension Service. 1-33.

Sutton CL, Taylor ZE, Farone MB, Handy ST. (2017) Antifungal activity of substituted aurones. Bioorganic and Medicinal Chemistry Letters. 27: 901-903.

Bi, W., Gao, Y., Shen, J., He, C., Peng, Y., Zhang, C., Xiao, P. G. (2016) Traditional uses, phytochemistry and pharmacology of the genus of Acer (maples): A review. Journal of Ethnopharmacology. 189: 31-60.

Bi, W., Shen, J., Gao, Y., Peng, Y., He, C., Xiao, P. G. (2016) Ku-jin tea (Acer tataricum subsp. ginnala and A. tataricum subsp. theiferum), an underestimated functional beverage rich in antioxidant phenolics. Journal of Functional Foods. 24: 75-84.

Gao, Y., He, C. (2017) Anti-proliferative and anti-metastasis effects of ten oligostilbenes isolated from the seeds of Paeonia suffruticosa against human cancer cells. Oncology Letters. 13: 4371-4377.

Taylor, K.M., Taylor, Z.E., Handy, S.T. (2017) Rapid synthesis of aurones under mild conditions using a combination of microwaves and deep eutectic solvents. Tetrahedron Lett. 58:  240-241.

Gao, Y., Wang, X., He, C. (2016) An isoflavonoid-enriched extract from Pueraria lobata (Kudzu) root protected human umbilical vein endothelial cells against oxidative stress-induced apoptosis. Journal of Ethnopharmacology. 193: 524-530.

Kelley, M., Gao, Y, Erenso, D. (2016) Single BT20 breast carcinoma cell ionization by laser trap for accurate radiotherapy. Biomedical Optics Express. 7: 3438-3448. 

Liu, X., Dong, H., Wang, M., Gao, Y., Zhang, T., Hu, G., Duan, H., Mu, X. (2016) IL-1α-induced microvascular endothelial cells promote neutrophil killing by increasing MMP-9 concentration and lysozyme activity. Immunological Research. 64:133-142.

Park, H.S., Vick E.J., Gao, Y., He, C., Almosnid, N.M., Farone, M., Farone, A.L. (2016) Cis-and trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells. Journal of Ethnopharmacology. 189: 202-209.

Pathiranage, A.L., Stubblefield, J.M., Zhou, X., Miao, J., Newsome, A.L., Dunlap, N. (2016) Antitrypanosomal activity of iridals from Iris domestica. Phytochemistry Letters. 18: 44-50. 

Almosnid, N., Gao, Y., He, C., Park, S., Altman, E. (2015) In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D isolated from Paeonia suffruticosa seeds. International Journal of Oncology. 48: 646-656.

Gao, Y., He, C., Bi, W., Wu, G., & Altman, E. (2015) Bioassay guided fractionation identified hederagenin as a major cytotoxic agent from Cyclocarya paliurus Leaves. Planta Medica. 82: 171-179.

Gao, Y., He, C., Ran, R., Zhang, D., Li, D., Xiao, P. G., & Altman, E. (2015) The resveratrol oligomers, cis-and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines. Journal of Ethnopharmacology. 169: 24-33.

Gao, Y., Huang, R., Gong, Y., Park, H. S., Wen, Q., Almosnid, N. M., Chippada-Venkata, U. D., Hosain, N. A., Vick, E., Farone, A., Altman, E. (2015) The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells. Oncotarget. 6: 24304-24319. 

Dunlap, N., Salyard, T.L.J., Pathiranage, A.L., Stubblefield, J.M., Pitts, S.L., Ashley, R.E., Osheroff, N. (2014) Synthesis and evaluation of ether-linked dimers of demethylepipodophyllotoxin dimmers. Bioorganic and Medicinal Chemistry Letters. 24: 5627-5629.

Wright, M.E., Byrd, J., He, C., Dunlap, N. (2014) Synthesis of cyclocaric acid A and comparison to material from Cyclocarya paliurus. Journal of Natural Products. 77: 2566-2569.

Hawkins, I., Handy, S.T. (2013) Synthesis of aurones under neutral conditions using a deep eutectic solvent. Tetrahedron. 69: 9200-9204. 

Pellizzaro, A., Welke, G., Scott, D., Solomon, R., Cooper, J., Farone, A., Farone, M., Mushi, R.S., Aguina, M.D., Erenso, D. (2012) Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient. Biomedical Optics Express. 3: 2190-2199.