Research Publications
Almosnid, N.M., Zhou, X., Jiang, L., Ridings, A., Knott, D., Wang, S., Wei, F., Yuan, J., Altman, E., Gao, Y., Miao, J. (2018) Evaluation of extracts prepared from 16 plants used in Yao ethnomedicine as potential anticancer agents. Journal of Ethnopharmacology. 211: 224-234.
https://doi.org/10.1016/j.jep.2017.09.032
Chen, C., Chen, W., Li, Y., Dong, Y., Teng, X., Nong, Z., Pan, X., Gao, Y., Wu, G. (2017) Hyperbaric oxygen protects against myocardial reperfusion injury via the inhibition of inflammation and the modulation of autophagy. Oncotarget. 8: 111522-111534.
https://doi.org/10.18632/oncotarget.22869
Chen, L., Wei, Y., Zhao, S., Zhang, M., Yan, X., Gao, X., Li, J., Gao, Y., Zhang, Z., Gao, Y. (2018) Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H22 liver tumor-bearing mice. Scientific Reports. 8: 10523.
https://doi.org/10.1038/s41598-018-28440-8
Alsaif, G., Almosnid, N.M., Hawkins, I., Taylor, Z., Knott, D.L.T., Handy, S., Altman, E., Gao, Y. (2017) Evaluation of fourteen aurone derivatives as potential anti-cancer agents. Current Pharmaceutical Biotechnology. 18: 384-390.
https://doi.org/10.2174/1389201018666170502112303
Chen, C., Nong, Z., Xie, Q., He, J., Cai, W., Tang, X., Chen, X., Huang, R., Gao, Y. (2017) 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione inhibits the growth and metastasis of breast carcinoma in mice. Scientific Reports. 7: 6704.
https://doi.org/10.1038/s41598-017-07162-3
Jiang, L., Wu, L., Yang, F., Almosnid, N., Liu, X., Jiang, J., Altman, E., Wang, L., Gao, Y. (2017) Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents. Oncology Letters. 14: 3057-3064.
https://doi.org/10.3892/ol.2017.6475
Park, H.S., Nelson, D.E., Taylor, Z.E., Hayes, J.B., Cunningham, K.D., Arivett, B.A., Ghosh, R., Wolf, L.C., Taylor, KM, Farone, M.B., Handy, S.T., Farone, A.L. (2017) Suppression of LPS-induced NF-κB activity in macrophages by the synthetic aurone, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one. International Immunopharmacology. 43: 116-128.
https://doi.org/10.1016/j.intimp.2016.12.004
Smith, S., DuBois, J., Phillips, N., Clardy, A. (2017) Wild Simulant Production Methods for American Ginseng Farms in Tennessee. Tennessee Agricultural Extension Service. 1-33.
http://www.tnstate.edu/extension/documents/wild_stimulant_production_ginseng_tennessee.pdf
Sutton CL, Taylor ZE, Farone MB, Handy ST. (2017) Antifungal activity of substituted aurones. Bioorganic and Medicinal Chemistry Letters. 27: 901-903.
https://doi.org/10.1016/j.bmcl.2017.01.012
Bi, W., Gao, Y., Shen, J., He, C., Peng, Y., Zhang, C., Xiao, P. G. (2016) Traditional uses, phytochemistry and pharmacology of the genus of Acer (maples): A review. Journal of Ethnopharmacology. 189: 31-60.
https://doi.org/10.1016/j.pep.2016.04.021
Bi, W., Shen, J., Gao, Y., Peng, Y., He, C., Xiao, P. G. (2016) Ku-jin tea (Acer tataricum subsp. ginnala and A. tataricum subsp. theiferum), an underestimated functional beverage rich in antioxidant phenolics. Journal of Functional Foods. 24: 75-84.
https://doi.org/10.1016/j.jff.2016.04.002
Gao, Y., He, C. (2017) Anti-proliferative and anti-metastasis effects of ten oligostilbenes isolated from the seeds of Paeonia suffruticosa against human cancer cells. Oncology Letters. 13: 4371-4377.
https://doi.org/10.3892/ol.2017.5982
Taylor, K.M., Taylor, Z.E., Handy, S.T. (2017) Rapid synthesis of aurones under mild conditions using a combination of microwaves and deep eutectic solvents. Tetrahedron Lett. 58: 240-241.
https://doi.org/10.1016/j.tetlet.2016.12.015
Gao, Y., Wang, X., He, C. (2016) An isoflavonoid-enriched extract from Pueraria lobata (Kudzu) root protected human umbilical vein endothelial cells against oxidative stress-induced apoptosis. Journal of Ethnopharmacology. 193: 524-530.
https://doi.org/10.1016/j.jff.2016.04.002
Kelley, M., Gao, Y, Erenso, D. (2016) Single BT20 breast carcinoma cell ionization by laser trap for accurate radiotherapy. Biomedical Optics Express. 7: 3438-3448.
https://doi.org/10.1364/BOE.7.003438
Liu, X., Dong, H., Wang, M., Gao, Y., Zhang, T., Hu, G., Duan, H., Mu, X. (2016) IL-1α-induced microvascular endothelial cells promote neutrophil killing by increasing MMP-9 concentration and lysozyme activity. Immunological Research. 64:133-142.
https://doi.org/10.1007/s12026-015-8731-4
Park, H.S., Vick E.J., Gao, Y., He, C., Almosnid, N.M., Farone, M., Farone, A.L. (2016) Cis-and trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells. Journal of Ethnopharmacology. 189: 202-209.
https://doi.org/10.1016/j.jep.2016.05.042
Pathiranage, A.L., Stubblefield, J.M., Zhou, X., Miao, J., Newsome, A.L., Dunlap, N. (2016) Antitrypanosomal activity of iridals from Iris domestica. Phytochemistry Letters. 18: 44-50.
https://doi.org/10.1016/j.phytol.2016.08.025
Almosnid, N., Gao, Y., He, C., Park, S., Altman, E. (2015) In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D isolated from Paeonia suffruticosa seeds. International Journal of Oncology. 48: 646-656.
https://doi.org/10.3892/ijo.2015.3269
Gao, Y., He, C., Bi, W., Wu, G., & Altman, E. (2015) Bioassay guided fractionation identified hederagenin as a major cytotoxic agent from Cyclocarya paliurus Leaves. Planta Medica. 82: 171-179.
https://doi.org/10.1055/s-0035-1557900
Gao, Y., He, C., Ran, R., Zhang, D., Li, D., Xiao, P. G., & Altman, E. (2015) The resveratrol oligomers, cis-and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines. Journal of Ethnopharmacology. 169: 24-33.
https://doi.org/10.1016/j.jep.2015.03.074
Gao, Y., Huang, R., Gong, Y., Park, H. S., Wen, Q., Almosnid, N. M., Chippada-Venkata, U. D., Hosain, N. A., Vick, E., Farone, A., Altman, E. (2015) The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells. Oncotarget. 6: 24304-24319.
https://doi.org/10.18632/oncotarget.4475
Dunlap, N., Salyard, T.L.J., Pathiranage, A.L., Stubblefield, J.M., Pitts, S.L., Ashley, R.E., Osheroff, N. (2014) Synthesis and evaluation of ether-linked dimers of demethylepipodophyllotoxin dimmers. Bioorganic and Medicinal Chemistry Letters. 24: 5627-5629.
https://doi.org/10.1021/np500575q
Wright, M.E., Byrd, J., He, C., Dunlap, N. (2014) Synthesis of cyclocaric acid A and comparison to material from Cyclocarya paliurus. Journal of Natural Products. 77: 2566-2569.
https://doi.org/10.1021/np500575q
Hawkins, I., Handy, S.T. (2013) Synthesis of aurones under neutral conditions using a deep eutectic solvent. Tetrahedron. 69: 9200-9204.
https://doi.org/10.1016/j.tet.2013.08.060
Pellizzaro, A., Welke, G., Scott, D., Solomon, R., Cooper, J., Farone, A., Farone, M., Mushi, R.S., Aguina, M.D., Erenso, D. (2012) Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient. Biomedical Optics Express. 3: 2190-2199.
